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pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can reduce panobinostat concentrations by ~70% and cause treatment failure.pentobarbital will lessen the level or result of darifenacin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Cautio